Generic Name: Tesamorelin
Form: Lyophilised powder (for reconstitution)
Strength: 10 mg per vial
Category: Synthetic peptide — growth hormone-releasing hormone (GHRH) analogue
Prescription Status: Prescription only (Rx) in most countries
What It Is
Tesamorelin is a synthetic analog of human growth hormone-releasing hormone (GHRH) — essentially a lab-made peptide that mimics the naturally occurring hormone your body produces to signal the pituitary gland to release growth hormone.
How It Works
Instead of supplying growth hormone itself, Tesamorelin stimulates your body to release its own growth hormone in a more natural, physiologic pattern. This activation happens through binding to GHRH receptors in the pituitary gland, increasing production of growth hormone and then insulin-like growth factor-1 (IGF-1).
Primary Use
📌 Clinically approved for reducing excess visceral (abdominal) fat in adults with HIV-associated lipodystrophy — a condition where fat is abnormally redistributed, often due to antiretroviral therapy.
It is not approved for general weight loss and should not be used as such.
Administration
Provided as a powder that must be reconstituted (mixed with a sterile diluent) before use.
Given by subcutaneous injection (under the skin), typically once daily.
Standard therapeutic doses in clinical settings are usually lower than 10 mg per day (e.g., 1–2 mg daily after reconstitution) — the 10 mg vial size simply provides enough peptide for multiple doses depending on the prescribed regimen.
Key Effects
✅ Targets and reduces visceral abdominal fat
✅ Works through natural hormonal pathways rather than direct hormone supplementation
✅ Helps improve metabolic parameters related to fat distribution
Common Side Effects
Possible effects may include:
Injection site reactions (redness, itching, pain)
Joint or muscle discomfort
Fluid retention or edema
Changes in glucose tolerance or elevated IGF-1 levels
Side effects are usually mild to moderate and should be discussed with a healthcare provider.





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